Fully agree with Taffy. That is what I understand from talking to people here and there.
One source I trust is Ljunggrens motor in Sweden where I bought my 570. He had put an acra header on the bench and it showed no more HP than stock, it had however 2dB less.
He told me that one could have a different, more open, silencer to remove some heat and it could benefit top end. But it wasn't much of a difference.
I have heard from a different source that the HP benefit compared to stock is negligible, that it even might be a loss. But then people talk about engine characteristics, loose top HP and gain in curve. I will not touch that as there is so much psychology with sounds
Tomtom has found out, amongst other tuners, that the bottle neck is to get air into the engine. But that is for 570s as they are based on the 390/450 using the same throttle body.
Imho a 390 is very good as it is. Just make sure your injector and air filter are clean. You could try to tune it following Alans advice if you like to make it a bit richer, and maybe even open up the silencer as Rainero says.
What make people believe these bikes are tamed, that they have more to give, is the very nice mapping curve. They deliver in a very linear fashion. Accelerate next to a "wilder" machine and I'm quite sure you will keep up with it