Hi Pollo,
Keeping in mind that the range of the ps is between 1 & 1/4 turns out and 2 & 1/2 turns out......
If you want a good starting point, with bike warmed up fully and idling normally, turn the ps in until the motor starts to slow down, then back out 1 turn to 3/4 of a turn and that should put you in the ball park.
If the motor won't slow down or die when you turn the ps all the way in, the pilot jet is too big. If you have to open the ps to 2 &1/2 turns out then you could probably use a richer pilot jet.
If you haven't already, you might have a look at the doc and check out the paj and pj chart. Once you have this set right 1/4 turns to the ps will reap big changes in how the bike is running as you will have the air ratio set right for a given pj size. For instance, I have a adjustable pas or paj in my bike and it is set for the 38 pilot that I have in my carb. During the winter in the desert, my ps is set around 2 &1/4 turns out, and yet I can go up to 9000' and it can be 80 degree's and I'll be down around 1 & 1/4 turns out.
Of course, you also have to make sure that you have the right needle straight on your needle etc...
Since you mentioned changing altitudes, and Fry mentioned not changing altitudes but changing pressures and temperatures, which is also known as "density altitude", I have included the linked density altitude calculator. If you use the noaa.gov site and pick the nearest weather station to your favorite riding locations, you can get the required inputs and check out what the density altitude changes are. It might surprise you how much higher in elevation the motor thinks it is based on temperature, humidity, baro pressure, and altitude.
http://wahiduddin.net/calc/calc_da.htm